| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML4290-5MG | 5 mg | |
| SML4290-25MG | 25 mg |
≥98%（HPLC）
AU-24118 is an orally active, potent and selective SWI/SNF ATPase degrader composed of an E3 ligase cereblon (CRBN) ligand linked to the SMARCA2/4 and PBRM1 (PB1)-selective bromodomain (BrD) inhibitor SGC-SMARCA-BRDVIII. AU-24118 induces near complete degradation of cellular SMARCA2/4 and PBRM1 (4-8h, 100 nM, 22Rv1 cells) and blocks SWI/SNF-dependent survival in cancer cultures (IC50 <100 nM post 5-day treatment; C42B, LNCaP, 22Rv1, VCaP). AU-24118 induces tumor regression in a castration-resistant prostate cancer (CRPC) VCaP xenograft model (15 mg/kg 3x/wk via p.o.) and is enhanced with concurrent AR antagonist enzalutamide treatment (10 mg/kg 5x/wk via p.o.).
| 英文名称 | AU-24118 hydrochloride |
| CAS 号 | 3084244-26-5 |
| 经验分子式 | C37H40N6O4 · xHCl |
| 分子量 | 632.75（以游离碱计） |
| UNSPSC | 41116107 |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 储存条件 | 干燥 |
| 颜色 | 淡黄色到橙色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | -10 到 -25°C |
| 质量等级 | 100 |
| 包装规格（货号 SML4290-5MG） | — |
| 包装规格（货号 SML4290-25MG） | — |
