| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML4148-5MG | 5 mg |
≥98%（HPLC）
LY 341495是一种代谢型谷氨酸受体拮抗剂，可用于研究谷氨酸信号在各种生理和病理过程中的作用，也可用于神经生物学研究，特别是了解突触传递/神经递质释放的机制PMID 27872019、突触可塑性PMID 35742857和神经元兴奋性PMID 21139059。
Potent antagonist against group II metabotropic glutamate receptors mGluR2 and mGluR3. LY341495 (LY 341495,LY-341,495, LY-341495) is a group II metabotropic glutamate receptor antagonist that potently reverses 3 μM mGluR agonist ACPD-dependent inhibition of forskolin-induced cAMP production in cells expressing either human mGluR2 ormGluR3 (IC50 = 21 nM and 14 nM, respectively), being much less potent against mGluR8, mGluR7, mGluR1a, mGluR5a, and mGluR4 (IC50 = 0.17, 0.99, 7.8, 8.2, 22μM, respectively). LY341495 is widely used for studying mGluR2/3-dependent cellular and physiological functions both in cultures in vitro and in animals in vivo (1-10 mg/kg via i.p. or s.c.).
| 英文名称 | LY341495 |
| CAS 号 | 201943-63-7 |
| 经验分子式 | C20H19NO5 |
| 分子量 | 353.37 |
| MDL 号 | MFCD00949707 |
| NACRES | NA.21 |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至深灰色 |
| 溶解性 | 1 M NaOH：2 mg/mL，澄清 |
| 储存温度 | -10 到 -25°C |
| 质量等级 | 100 |
| 包装规格（货号 SML4148-5MG） | 5 mg |
