Sigma-Aldrich Alginate，纯化

产品概述

海藻酸盐是一组线性多糖，由β- D -甘露糖醛酸（M）和它的C-5差向异构体α-L-古洛糖醛酸（G）单元以各种序列或嵌段共价键合而成。这些多糖可以从自然界中发现的许多种褐藻中提取。我们纯化的海藻酸盐外观为白色至类白色，分子量为20-80 kDa。

应用领域

Alginate, Purified is an anionic polysaccharide designed for using in R&D applications in pharmaceutical and biomedical applications due to its non-animal origin, low toxicity, biocompatibility, and biodegradability. PMID 11077410This low endotoxin version of alginate methacrylate is specifically designed for biomedical use. Alginate hydrogels are commonly employed to create tissue engineering scaffolds, bioinks for 3D bioprinting, and nanocarriers for drug and gene delivery.PMID 24998183PMID 27898010PMID 20704471 While alginate is typically crosslinked into a hydrogel via ionic crosslinking with divalent cations (e.g., Ca²⁺), these gels often exhibit limited long-term stability due to exchange reactions and the migration of cations from the alginate matrix. To enhance matrix stability, alginate can be functionalized with reactive groups for chemical crosslinking, such as methacrylates. Methacrylate-functionalized alginate allows for the preparation of hydrogels through thermal or photochemical crosslinking of the terminal methacrylates. The properties of the resulting hydrogels, including stiffness, swelling ratio, and degradation rate, can be tailored by adjusting the alginate molecular weight, degree of methacrylate functionalization, and crosslink density.

产品特点

这种特定的分子量范围（20-80 kDa）提供了最佳的粘度和凝胶强度，允许在组织工程、药物递送和生物打印中的定制应用，增强了这些领域的性能和功效。

技术规格