Sigma-Aldrich AT2R agonist C21，≥98%（HPLC法），血管紧张素II受体激动剂，粉末

产品概述

≥98%（HPLC法），血管紧张素II受体激动剂，粉末

应用领域

AT 2 R激动剂C21可用于研究：C21在来源于野生型和AT 2 R敲除（AT 2 R-/y）小鼠的小鼠肠系膜动脉中的血管舒张作用、C21对U46619诱导的β-arrestin募集至TP受体的作用以及C21对U46619诱导的血小板聚集的作用PMID 36894067

生化/生理作用

C21 (Buloxibutid; Compound 21; M024) is a potent and selective angiotensin II receptor (AT2R) nonpeptide agonist (Ki = 0.4 nM/AT1R vs. >10 µM/AT1R) that induces AT2R-mediated morphological changes in NG 108-15 neuroblastoma-glioma hybrid cells (100 nM for 3 days), blockable by AT2R antagonist PD 123,319 (1 µM). C21 enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats (30 & 300 µg/kg/h via i.v.), and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats in vivo (50 µg/kg/h via i.v.). C21 shares structural similarities with AT1-receptor antagonists irbesartan and losartan, and may show TP-receptor antagonistic properties.PMID 36894067

技术规格