Sigma-Aldrich Cholesteryl methacrylate，≥95%

产品概述

胆固醇甲基丙烯酸酯（ChMA）是一种混合单体，它将胆固醇的生物相容性、疏水性与甲基丙烯酸酯的可聚合功能性结合在一起，这种独特的组合使设计用于生物医学和纳米技术应用的先进材料成为可能。胆固醇部分赋予类脂质行为，促进膜相互作用并增强在水环境中的稳定性，而甲基丙烯酸酯基团通过常规或可控聚合促进聚合物网络的结合。这些双重特性使ChMA成为两亲聚合物、水凝胶和具有可调性质的纳米结构的理想构建单元。

应用领域

Cholesteryl Methacrylate is a specialized methacrylate monomer that plays a significant role in the development of advanced materials and biomedical applications. This compound is particularly valuable in the synthesis of cholesterol-based polymers, which exhibit unique properties such as biocompatibility and structural stability. Due to its hydrophobic nature, Cholesteryl Methacrylate can be utilized to create polymeric systems that mimic biological membranes, making it suitable for applications in drug delivery and tissue engineering. In drug delivery systems, Cholesteryl Methacrylate can enhance the solubility and stability of therapeutic agents, facilitating their controlled release and improving bioavailability. Its incorporation into polymeric carriers allows for the design of smart delivery systems that respond to specific stimuli, thereby optimizing therapeutic efficacy. Recent research demonstrated that Vincristine sulfate (VCR), encapsulated within polymerized liposomes, achieved prolonged and sustained drug release during in vitro studies conducted in phosphate-buffered saline (pH 7.4) and 1% human plasma. This monomer is utilized to create biocompatible hydrogels and scaffolds that mimic biological membranes, promoting cell adhesion and tissue regeneration. Research highlights its role in developing scaffolds for regenerative medicine. Cholesteryl methacrylate demonstrates cholesteric (chiral nematic) mesophases, a defining feature of cholesterol-based liquid crystalline materials. This property enables its use in advanced applications such as optoelectronics—reflective displays and tunable photonic crystals—and smart materials, including temperature-responsive coatings and sensors.[3]

技术规格