| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML4376-10MG | 10 mg | |
| SML4376-50MG | 50 mg |
≥98%（HPLC）
The MFS03 (maleimido fluorosulfonyl) linker is a heterobifunctional covalent tether that converts affinity proteins (affibody and monobody) into irreversible therapeutics. MFS03 features a maleimide for cysteine conjugation and a bio-orthogonal aryl fluorosulfate warhead on a flexible spacer (2.92–17.7 Å), which initiates a proximity-enabled Sulfur(VI) Fluoride Exchange (SuFEx) reaction with target nucleophiles like histidine or lysine. On HER2/EGFR scaffolds, this covalent anchoring enhances therapeutic performance, yielding >2-fold tumor retention, 185% higher cellular uptake, and near-complete tumor inhibition. This permanent binding decouples pharmacodynamics from pharmacokinetics, boosting cytotoxicity 2.5- to 4.9-fold (to 0.31 nM) while maintaining a favorable biosafety profile.
| 英文名称 | MFS03 |
| CAS 号 | 3089116-28-6 |
| 经验分子式 | C15H15FN2O6S |
| 分子量 | 370.35 |
| UNSPSC | 12352200 |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | -10 到 -25°C |
| 质量等级 | 100 |
| 包装规格（货号 SML4376-10MG） | — |
| 包装规格（货号 SML4376-50MG） | — |
