Sigma-Aldrich 3,5-tBu-CyFPhos，≥95%

产品概述

3,5-tBu-CyFPhos [dicyclohexyl(3′,5′-di-tert-butyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphane ] is an electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.PMID 39288263The 3,5 tert-butyl groups on the biaryl moiety provide an ideal steric profile to resist N-heteroarene-mediated catalyst deactivation while still facilitating the binding of large secondary amines to the active catalyst.

应用领域

3，5-t Bu-CyFPhos已用于：-Pd催化的仲胺芳基化。PMID 39288263

产品特点

FPhos-type catalysts effectively resist N-heteroarene-mediated catalyst deactivation, readily promoting C–N coupling between a wide variety of Lewis-basic aryl halides and secondary amines, including densely functionalized pharmaceuticals.PMID 39288263

技术规格