| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML4411-50MG | 50 mg |
≥98%（HPLC）
N6F11 is a ferroptosis inducer (0.5-10 µM for 24h) that causes cellular glutathione peroxidase 4 (GPX4) degradation (5 µM for 6-12h, 0.0625-5 µM for 12h) via ubiquitin-proteasome system (UPS) by inducing TRIM25-mediated ubiquitination. N6F11 causes ferroptotic cancer cell death that initiates HMGB1-dependent antitumor immunity mediated by CD8+ T-cells. When administered together with CD274 neutralizing antibody (clone 10F.9G2), N6F11 prolongs the average life expectancy of KPC mice, an orthotopic pancreatic ductal adenocarcinoma (PDA) model in vivo (10 mg N6F11/kg, 20 mg αCD274/kg via i.p.). Unlike RSL3, Fin56, and erastin, autophagy is dispensable of N6F11-induced ferroptosis.
| 英文名称 | N6F11 |
| CAS 号 | 851398-76-0 |
| 经验分子式 | C13H8Cl2N2OS |
| 分子量 | 311.19 |
| UNSPSC | 12352200 |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 溶解性 | 二甲基亚砜（DMSO）：2 毫克/毫升，透明（加热） |
| 储存温度 | -10 到 -25°C |
| 质量等级 | 100 |
| 包装规格（货号 SML4411-50MG） | — |
