Sigma-Aldrich Ubiquitin Carrier Protein H2 human

生化/生理作用

UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event. TNF-α was shown to stimulate expression of UbcH2 in skeletal muscle cells by increasing binding of NFκ-B to the promoter region of UbcH2, inducing transcription. PMID 12773487

UbcH 2是酵母DNA修复基因RAD 6的人类同源基因，可被DNA损伤剂诱导，也与癌症诱导的恶病质和“N-末端规则”底物的降解有关。肌肉中UbcH 2 mRNA的水平也与脓毒症有关。此外，c-Jun和c-Fos转录因子已被证明通过UbcH 2介导的事件被泛素化。

物理形态

溶于50 mM HEPES、50 mM NaCl、10%甘油、1 mM DTT中的溶液，pH 7.8

其他说明

由波士顿生物化学有限公司为Sigma制造。

技术规格