Sigma-Aldrich α-synuclein 61-140, human

产品概述

产品来源：大肠埃希菌

Alpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human. There are two other known synuclein family members, beta- and gamma-synuclein. Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson′s disease (PD). Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388). Clone Syn211, Cat. No. 36-008-C detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, Cat. No. MABN824, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).

在N-末端附加一个额外的氨基酸（Met）。

应用领域

研究类别神经科学

研究亚类神经退行性疾病

物理形态

白色冻干粉末，以1 mg/mL的浓度重悬于无菌水中，最终浓度为20 mM Tris/HCl，pH 7.5，100 mM NaCl。

制备/使用说明

冻干品自接收之日起在-20 ° C下保存12个月，复溶后在-20 ° C至-70 ° C下保存2周，避免冻融循环，以避免聚集。

技术规格