Sigma-Aldrich Brain Derived Neurotrophic Factor, recombinant

产品概述

FUNCTION: SwissProt: P23560 # Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
SIZE: 247 amino acids; 27818 Da
SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
SUBCELLULAR LOCATION: Secreted.
PTM: The propeptide is N-glycosylated and glycosulfated. & Converted into mature BDNF by plasmin (PLG) (By similarity).
DISEASE: SwissProt: P23560 # Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.
SIMILARITY: SwissProt: P23560 ## Belongs to the NGF-beta family.

应用领域

大多数体外应用的浓度范围为0.5 - 100 ng/mL。应答细胞为（部分列表）：神经、胶质细胞。

物理形态

无菌过滤，冻干，不含添加剂。

制备/使用说明

冻干粉末在室温下稳定，但最好在0°C以下干燥保存。用水复溶至浓度为0.1-1.0 mg/mL。该溶液可以用水或其他缓冲溶液稀释。复溶的BDNF应在-20 ° C下以未稀释的等分试样保存长达6个月。避免重复冻融循环。

技术规格