![Sigma-Aldrich 2-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid](/img/sigma/114287-1.webp)
| 货号 | 包装规格 | 操作 |
|---|---|---|
| 920592-50MG | 50 mg |
2-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920711
920614
920622
920630
入口：构建用于靶向蛋白质降解的PROTAC ®降解剂生物结合技术交联剂聚焦：用于靶向蛋白质降解的降解剂构建模块
| 英文名称 | 2-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid |
| 经验分子式 | C20H26N2O5 |
| 分子量 | 374.43 |
| MDL 号 | MFCD34602190 |
| UNSPSC | 12352106 |
| NACRES | NA.22 |
| InChI key | WBMOMEUOIOTVRJ-UHFFFAOYSA-N |
| SMILES字符串 | C = C（O）C = C（O）C（O） |
| 形态 | 粉末 |
| 反应适用性 | 试剂类型：连接器 |
| 官能团 | 羧酸 |
| 储存温度 | 2-8°C |
| 质量等级 | 100 |
| 包装规格（货号 920592-50MG） | 50 mg |
