| 货号 | 包装规格 | 操作 |
|---|---|---|
| SCT246 | 1 mg |
DNA/RNA G-quadruplexes (G4s) are four-stranded nucleic acid structures that fold from numerous guanine (G)-rich sequences found in the genome and transcriptome. Their abundance and localization in critical regulatory regions make them key players in genetic diseases (cancer, neuropathology), but not only (e.g., viral infection). For this reason G4s have garnered intense interest as potential targets in different therapeutic areas.
The BioTracker™ BioCyTASQ G-quadruplex G4 cell probe is optimized for detection (1) and/or the isolation of G4s (2,3). BioCyTASQ utilizes the template-assembled synthetic G-quartets (TASQ) (4) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.
References1.ACS Chem Biol. 2021, 16: 905–914 2. Nature Protoc. 2022, 17: 870–889 3. STAR Protoc. 2024, 5: 103480 4. Acc. Chem. Res. 2023, 56: 350–362 5. iScience 2023, 26:106846
纯度：经HPLC、HNMR、LC-MS和元素分析确认> 98%
BioCyTASQ适合于在称为预靶向G4成像的2步方案中使细胞中的G4可视化，其依赖于荧光链霉亲和素的使用（1）BioCyTASQ还适合于通过亲和捕获实验分离G4，在用于RNA G4的名为G4 RP的方案中（2，这些G4选择性化学沉淀允许通过PCR、RT-PCR或测序对其进行鉴定。
冻干。白色固体。
将BioTracker BioCyTASQ G-quadruplex G4细胞探针储存在-20 ° C下，干燥并避光
细胞和组织中核酸G4四链体的荧光检测
| 英文名称 | BioTracker BioCyTASQ G-Quadruplex (G4) Cell Probe |
| NACRES | NA.47 |
| UNSPSC | 41106514 |
| 包装 | 1 mg小瓶 |
| 制造商/商标 | Millipore |
| 增长方式 | N/A |
| 技术 | DNA测序：适宜; RNA提取：适宜;核酸检测：适宜 |
| 检测方法 | 荧光测定 |
| 运输状态 | 干冰 |
| 储存温度 | −20°C |
| 质量等级 | 100 |
| 包装规格（货号 SCT246） | 1 mg |
