| 货号 | 包装规格 | 操作 |
|---|---|---|
| SMB01003-1MG | 1 mg |
Cyclopenin是一种苯并二氮杂类生物碱，是青霉属真菌Penicillum cyclopium、Penicillium aurantiogriseum和Penicillum corymbiferum的天然产物，具有抗菌、抗病毒、抗肿瘤、抗炎和神经保护等多种生物活性。
它是一种来源于植物的天然产物，可用于化合物筛选库、代谢组学、植物化学和药物研究。
According to existing research, Cyclopenin displays selective inhibition against acetylcholinesterase (AChE). Furthermore, it demonstrates anti-inflammatory properties by inhibiting nitric oxide production, NF-κB activation, and the expression of inflammatory factors such as IL-1β, IL-6, and iNOS in brain macrophages. In an Alzheimer′s disease model, Cyclopenin exhibited the ability to rescue learning deficits induced by amyloid-β42 overexpression in flies, indicating its potential as an anti-inflammatory agent for neurodegenerative diseasesPMID 32210361. Isolated from Penicillium polonicum MCCC3A00951, Cyclopenin displayed potent inhibition of influenza neuraminidase (NA) with an IC50 value of 5.02μM, suggesting its potential as a candidate for anti-influenza NA therapy. Cyclopenin, identified in the fungus Penicillium auratiogriseum Sp-19, demonstrated cytotoxicity against the tsFT210 cell line at a concentration of 3 μg/mL-1, implying its potential as an antitumor agent.(3)Cyclopenin, isolated from Penicillium polonicum MCCC3A00951, exhibited strong inhibition of influenza neuraminidase (NA) with an IC50 value of 5.02μM. This suggests that Cyclopenin has the potential to be developed as an anti-influenza NA candidate.
适用于多种研究应用的高品质化合物兼容HPLC和质谱技术
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| 英文名称 | Cyclopenin |
| CAS 号 | 20007-87-8 |
| 经验分子式 | C17H14N2O3 |
| 分子量 | 294.30 |
| UNSPSC | 12352205 |
| NACRES | NA.25 |
| SMILES字符串 | N，N ′-二氯-2，3，4，5，6，7，8，9，10，1 |
| InChI | 1S/C17H14N2O3/c1-19-15(20)12-9-5-6-10-13(12)18-16(21)17(19)14(22-17)11-7-3-2-4-8-11/h2-10,14H,1H3,(H,18,21) |
| InChI key | 阿普拉姆-乌夫法奥萨-北 |
| 生物来源 | 植物 |
| 含量测定 | ≥90%（LC/MS-ELSD） |
| 形态 | 固体 |
| 分子量 | 294.3 |
| 溶解性 | 水：微溶 |
| 应用 | 代谢组学维生素、保健品和天然产品 |
| 储存温度 | −20°C |
| 包装规格（货号 SMB01003-1MG） | 1 mg |
