Sigma-Aldrich β-Endorphin human，≥95%（HPLC）

产品概述

β-Endorphin is a potent endogenous opioid protein that is derived from propiomelanocortin, a protein found in the brain, anterior pituitary, skin, immune system, and other peripheral sites. β-endorphin, however, is localized to the brain and spinal cord. It is one of the major opioid peptides, and is the derivative of the C-terminal of β-lipotropin. It is made of 31 amino acids.PMID 9593217PMID 16912690

应用领域

Human β-Endorphin is suitable for-
radioimmunoassay to determine the portal blood β-endorphin levels in lactating ewes, and its relation to bouts of sucklingPMID 2952792to assess the melanogenesis, proliferation and dendricity of melanocytesPMID 12787137to assess the expression of μ-opioid receptor, in human skin organ culture, on exposure to β-endorphinPMID 10692113to examine the effects on cardiovascular functions of β-endorphin injection nucleus in amygdaloideus centralis (AC), into either nucleus paraventricularis (NPV) or rostral ventrolateral medulla (RVL)PMID 11514030

生化/生理作用

β-内啡肽在大脑的不同部位充当μ和δ阿片受体的配体。PMID 9593217它在对疼痛刺激作出反应时释放，并具有强效的抗伤害感受活性。当在棘上给药时，这种活性是通过作用于脑内的ε-阿片受体，导致甲硫氨酸脑啡肽的释放而介导的，也是通过与δ2-阿片受体的相互作用而介导的。脊髓中的阿片受体。当鞘内引入时，该功能是其与大鼠μ和κ阿片受体相互作用的结果。PMID 7643909在自身免疫性疾病中，细胞因子的产生增加导致垂体和淋巴细胞中β-内啡肽的产生。β-内啡肽作为抗体产生的负调节剂，因此，与自身免疫性疾病有关。PMID 8822274

一种有效的内源性阿片样蛋白，来源于黑皮质素原，一种在脑、垂体前叶、皮肤、免疫系统和其它外周部位发现的蛋白质。它在疼痛刺激时释放，并具有有效的抗伤害感受活性，通过其对脑中μ受体的作用以及脊髓中μ和κ受体的作用介导。

强效内源性阿片样蛋白;对疼痛刺激作出反应而释放，并具有强效的抗伤害感受活性。

其他说明

从0.1% TFA的H2O溶液中冻干

技术规格