| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML3477-5MG | 5 mg | |
| SML3477-25MG | 25 mg |
≥95%（HPLC）
Orally active, high-affinity, potent and selective trace amine-associated receptor 1 (TAAR1) agonist with antipsychotic-like efficacy in vivo.
RO5166017 is an orally active, high-affinity, potent and selective trace amine-associated receptor 1 (TAAR1) agonist (mouse/rat/human/monkey Ki = 1.9/2.7/31/24 nM, cAMP EC50 = 3.3/14/55/97 nM using respective HEK293 transfectants; GIRK EC50 = 8 nM with mTAAR1-expressing Xenopus oocytes; neurons firing frequency IC50 = 1.73/2.99 nM in mouse VTA/DRN slices) with good selectivity over TAAR4 and 123 other proteins. RO5166017 reduces spontaneous hyperlocomotion in Dat-/- mice (0.5 mg/kg ip.), as well as hyperlocomotion induction by cocaine or NMDAR agonist L-687,414 in wild-type (0.01-0.3 mg/kg po.), but not Taar1-knockout mice.
| 英文名称 | RO5166017 |
| CAS 号 | 1048346-74-2 |
| 经验分子式 | C12H17N3O |
| 分子量 | 219.28 |
| UNSPSC | 12352200 |
| NACRES | NA.77 |
| MDL 号 | MFCD22493512 |
| SMILES字符串 | N1[C@H](COC1=N)CN(CC)c2ccccc2 |
| InChI key | PPONHQQJLWPUPH-JTQLQIEISA-N（巴基斯坦） |
| 含量测定 | ≥95%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | -10 到 -25°C |
| 质量等级 | 100 |
| 包装规格（货号 SML3477-5MG） | 5 mg |
| 包装规格（货号 SML3477-25MG） | 25 mg |
