| 货号 | 包装规格 | 操作 |
|---|---|---|
| G1276-250UG | 250 μg | |
| G1276-1MG | 1 mg |
Gastrin is a pyloric antral hormone, which is a small biologically active peptide thatis synthesized as a precursor. It is found to be produced in antral G cells.PMID 1701434PMID 9751525
胃泌素I已用于大鼠胃泌素刺激研究，以测定高胃泌素血症和类癌条件下胃泌酸粘膜中组氨酸脱羧酶和组胺代谢的表达。PMID 8828505还用于大鼠免疫组织化学试验前抗胃泌素抗体的预吸收。PMID 9751525
Gastrin plays a crucial role in the maintenance of architecture and function of oxyntic mucosa of stomach, which is involved in the secretion of acid. It also triggers the secretion of acid into the gastric lumen.PMID 9751525 Continuous increased plasma levels of gastrin or hypergastrinemia, may be involved in gastrointestinal carcinogenesis, especially if it is accompanied with inflammation.PMID 21995960 The release of this peptide is suppressed during distention, which is a result of omatostatin and intrinsic cholinergic pathways.PMID 12508367 In rats, this peptide maintains gastric mucosal integrity through the up-regulation of cyclooxygenase-2 which is, in part, mediated by heparin-binding epidermal growth factor-like growth factor (HB-EGF).PMID 12388195
从0.1% TFA的H2O溶液中冻干
| 英文名称 | Gastrin I rat |
| CAS 号 | 81123-06-0 |
| 经验分子式 | C94H128N22O31S2 |
| 分子量 | 2126.28 |
| NACRES | NA.32 |
| UNSPSC | 51111800 |
| MDL 号 | MFCD00076501 |
| 基因信息 | 大鼠...胃（25320） |
| InChI | 1S/C94H128N22O31S2/c1-48(79(133)113-65(43-50-19-21-52(117)22-20-50)80(134)100-47-71(119)103-66(44-51-46-99-54-15-8-7-14-53(51)54)89(143)109-61(35-40-148-2)88(142)114-67(45-77(130)131)90(144)112-64(78(95)132)42-49-12-5-4-6-13-49)101-81(135)56(24-30-72(120)121)104-83(137)57(25-31-73(122)123)105-84(138)58(26-32-74(124)125)106-85(139)59(27-33-75(126)127)107-86(140)60(28-34-76(128)129)108-87(141)62(36-41-149-3)110-91(145)68-17-10-38-115(68)93(147)69-18-11-39-116(69)92(146)63(16-9-37-98-94(96)97)111-8 |
| SMILES字符串 | CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(Cc3ccc(O)cc3)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCSC)NC(=O)C4CCCN4C(=O)C5CCCN5C(=O)C(CCCNC(N)=N)NC(=O)C6CCC(=O)N6)C(=O)NC(CC(O)=O)C(=O)NC(Cc7ccccc7)C(N)=O |
| InChI key | 富图尼普什卡焦-乌夫法奥萨-N |
| 生物来源 | 大鼠 |
| 含量测定 | ≥97%（HPLC法） |
| UniProt 登录号 | P04563 |
| 储存温度 | −20°C |
| 质量等级 | 200 |
| 包装规格（货号 G1276-250UG） | 250 μg |
| 包装规格（货号 G1276-1MG） | 1 mg |
