| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML3428-5MG | 5 mg | |
| SML3428-25MG | 25 mg |
≥97%（HPLC法）
GLPG2938 is an orally active, potent and selective S1P2 receptor (S1PR2) antagonist (GTPγS induction IC50 = 29 nM; [S1P] = EC80) with no activity against other S1P receptors. GLPG2938 inhibits sphingosine 1-phosphate (S1P)-induced cellular responses in cultures (Ca2+ flux IC50 = 8.8 nM & IL8 release IC50 = 3.8 nM; [S1P] = EC80) and exhibits good efficacy in a 14-day model of bleomycin-induced pulmonary fibrosis in mice in vivo (1, 3, and 10 mg/kg b.i.d. p.o.) with good pharmacokinetics.
具有体外和体内疗效的口服活性、强效和选择性S1 β 2亚型选择性鞘氨醇-1-磷酸（S1 β）受体拮抗剂。
| 英文名称 | GLPG2938 |
| CAS 号 | 2130996-00-6 |
| 经验分子式 | C20H19F6N7O2 |
| 分子量 | 503.40 |
| UNSPSC | 12352200 |
| NACRES | NA.77 |
| MDL 号 | MFCD34563730 |
| InChI | 1S/C20H19F6N7O2/c1-4-35-15-7-11(6-14(29-15)19(21,22)23)28-18(34)27-8-12-5-10(2)16(31-30-12)13-9-33(3)32-17(13)20(24,25)26/h5-7,9H,4,8H2,1-3H3,(H2,27,28,29,34) |
| InChI key | 穆夫金-乌夫法伊沙-北 |
| SMILES字符串 | O=C（NCCl =CC（C）=C（C2=CN（C）N=C2C（F）（F）F）N=N1）NC3=CC（C（F）（F）F）=NC（OCC）=C3 |
| 含量测定 | ≥97%（HPLC法） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | -10 到 -25°C |
| 质量等级 | 100 |
| 包装规格（货号 SML3428-5MG） | 5 mg |
| 包装规格（货号 SML3428-25MG） | 25 mg |
