| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML4060-5MG | 5 mg | |
| SML4060-25MG | 25 mg |
≥98%（HPLC）
Blood-brain barrier (BBB)-permeable, far-red (near-IR) fluorescent contrast agent for staining of amyloid plaques with high specificity in situ and in vivo.
NIAD-4 is a blood-brain barrier (BBB)-permeable, far-red (near-IR) fluorescent contrast agent for staining of amyloid plaques with high specificity in situ (10 μM in DMSO/propylene glycol; APP mice coronal section) and in vivo (2 mg/kg APP mice i.v.). Due to its push-pull structure design and a greatly enhanced thioflavin T (ThT) site affinity (Ki = 10 nM/NIAD-4 vs 580 nM/ThT), NIAD-4 exhibits significantly red-shifted (~70 nm) absorption and a 1.3-fold increase in extinction coefficient upon binding aggregated amyloid-beta 1-40 (4.1 μM NIAD-4 & 10 μM amyloid-β in PBS). Ex 450-488 nm, Em 550-650 nm.
| 英文名称 | NIAD-4 |
| CAS 号 | 868592-56-7 |
| 经验分子式 | C18H10N2OS2 |
| 分子量 | 334.41 |
| MDL 号 | MFCD26097264 |
| NACRES | NA.28 |
| SMILES字符串 | OC1 = CC = C（C = C1）C2 = CC = C（S2）C3 = CC = C（S3）C = C（C#N）C#N |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | ，红色至深红色棕色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | 2-8°C |
| 质量等级 | 100 |
| 包装规格（货号 SML4060-5MG） | 5 mg |
| 包装规格（货号 SML4060-25MG） | 25 mg |
