| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML3111-5MG | 5 mg | |
| SML3111-25MG | 25 mg |
≥98%（HPLC）
ETP-47799 is a potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor (CDK8/19 IC50 = 2.9/14.1 nM; CDK1/5/9 IC50 = 275/239/124 nM; CDK2/4/6/7 IC50 >1 μM; GSK3β IC50 = 3.14 μM) with additional potency against PDGFRα (IC50 = 3.5 nM). ETP-47799 ( 0.4 μM or 1.1 μM) induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs) with better efficiency than the commonly used MEK/GSK3 inhibitor cocktail (1μM PD0325901, 1.5μM CHIR 99021).
诱导和稳定小鼠和人多能干细胞（PSC）幼稚状态的强效CDK 8/CDK 19选择性细胞周期蛋白依赖性激酶抑制剂。
| 英文名称 | ETP-47799 |
| CAS 号 | 923596-52-5 |
| 经验分子式 | C14H15N5 |
| 分子量 | 253.30 |
| UNSPSC | 12352200 |
| NACRES | NA.77 |
| InChI key | XTMROGQLIVGYKF-UHFFFAOYSA-北东印度公司 |
| SMILES字符串 | CCCNC1 = NN2C（C = C1）= NC = C2C3 = CC = NC = C3 |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | 2-8°C |
| 质量等级 | 100 |
| 包装规格（货号 SML3111-5MG） | 5 mg |
| 包装规格（货号 SML3111-25MG） | 25 mg |
