| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML4159-5MG | 5 mg | |
| SML4159-25MG | 25 mg |
≥98%（HPLC），粉末
AU-15330 may be usedin molecular biology and cancer research applications.
AU-15330 is a highly-selective proteolysis-targeting chimera (PROTAC) degrader of both SWItch/SucroseNon-Fermentable (SWI/SNF) adenosine triphosphatase (ATPase) subunits— SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 & 4 SMARCA2 (BRM)and SMARCA4 (BRG1) SWI/SNF ATPases. It potently inhibits tumor growth in xenograft models of prostate cancer. AU-15330 comprises a bait moiety that binds the bromodomain in SMARCA2 and SMARCA4 and a ligand moiety for the von Hippel–Lindau (VHL) ubiquitin ligase. It synergized with the androgen receptor antagonist enzalutamide.
| 英文名称 | AU-15330 |
| CAS 号 | 2380274-50-8 |
| 经验分子式 | C39H49N9O5S |
| 分子量 | 755.93 |
| MDL 号 | MFCD35063364 |
| NACRES | NA.21 |
| SMILES字符串 | NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N(CC3)CCN3CC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(N=CS6)C)C=C5)C)=O)=O)=O |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 质量等级 | 100 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | -10 到 -25°C |
| 包装规格（货号 SML4159-5MG） | 5 mg |
| 包装规格（货号 SML4159-25MG） | 25 mg |
