| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML3749-5MG | 5 mg | |
| SML3749-25MG | 25 mg |
≥98%（HPLC）
Orally active dopamine receptor D1-selective postive allosteric modulator (PAM) in vitro and in vivo.
UCM-1306 is an orally active dopamine receptor D1-selective postive allosteric modulator (PAM) void of D1 agonist activity. UCM-1306 potentiates dopamine (DA)-induced cAMP in the SK-N-MC neuroblastoma cell line with endogenous D1R (EC50/Emax = 60 nM/45% with [DA] = EC70; Emax = 55% with [DA] = 10 μM), but not D5R, by modulating DA affinity for the receptor, while displaying low binding competition against orthosteric ligands. UCM-1306 augments cocaine (20 mg/kg s.c.)-induced locomotion (1 mg/kg i.p.) and enhances L-DOPA (100-400 mg/kg i.p.) recovery of decreased locomotor activity in reserpinized (2.5 mg/kg s.c.) mice in vivo (30 mg/kg p.o.).
| 英文名称 | UCM-1306 |
| CAS 号 | 2258608-78-3 |
| 经验分子式 | C14H14FNO2S |
| 分子量 | 279.33 |
| NACRES | NA.28 |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO：2 mg/mL，澄清（加热） |
| 储存温度 | -10 到 -25°C |
| 质量等级 | 100 |
| 包装规格（货号 SML3749-5MG） | 5 mg |
| 包装规格（货号 SML3749-25MG） | 25 mg |
