| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML4091-5MG | 5 mg | |
| SML4091-25MG | 25 mg |
≥98%（HPLC）
Potent cyclin-dependent kinase-like 5 (CDKL5) and glycogen synthase kinase-3 (GSK3⍺/β) inhibitor with good kinome-wide selectivity.
SGC-CDKL5/GSK3-1 is a potent cyclin-dependent kinase-like 5 and glycogen synthase kinase-3 inhibitor (CDKL5/GSK3⍺/GSK3β IC50 = 6.5/4/9 nM by cell-free enzymatic assay, 3.5/10/35 nM by cellular NanoBRET) with good kinome-wide selectivity. SGC-CDKL5/GSK3-1 protects iPSC-derived motor neurons from ER stress-induced death.
| 英文名称 | SGC-CDKL5/GSK3-1 |
| CAS 号 | 844442-32-6 |
| 经验分子式 | C16H17F2N5O2 |
| 分子量 | 349.34 |
| NACRES | NA.28 |
| SMILES字符串 | O=C（NC1CCNCC1）C2=NNC=C2NC（C3=CC（F）=CC（F）=C3）=O = C（NC1CCNCC1）C2 = NNC =C2NC（C3=CC（F）= C（F）= C（F） |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | 2-8°C |
| 质量等级 | 100 |
| 包装规格（货号 SML4091-5MG） | 5 mg |
| 包装规格（货号 SML4091-25MG） | 25 mg |
