| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML1165-5MG | 5 mg |
≥98%（HPLC）
Talnetant (SB-223,412) is a highly selective antagonist of neurokinin 3 receptor with a Ki (NK3) = 1 nM >10000 (NK1) >140 (NK2). Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract. Talnetant was in clinical trials for both irritable bowel syndrome and schizophrenia.
Talnetant是一种高度选择性的神经激肽3受体拮抗剂。
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| 英文名称 | Talnetant |
| CAS 号 | 174636-32-9 |
| 经验分子式 | C25H22N2O2 |
| 分子量 | 382.45 |
| NACRES | NA.77 |
| UNSPSC | 12352200 |
| MDL 号 | MFCD00944075 |
| InChI | 1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1 |
| SMILES字符串 | OC(C(C(N[C@H](C1=CC=CC=C1)CC)=O)=C(C=CC=C2)C2=N3)=C3C4=CC=CC=C4 |
| InChI key | 转向节臂-数量 |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 光学活性 | [α]/D -25 to -31°, c = 0.5 in methanol |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO：25 mg/mL，澄清 |
| 储存温度 | 2-8°C |
| 质量等级 | 100 |
| 基因信息 | 人TACR 3（6870） |
| 包装规格（货号 SML1165-5MG） | 5 mg |
