| 货号 | 包装规格 | 操作 |
|---|---|---|
| PZ0387-5MG | 5 mg | |
| PZ0387-25MG | 25 mg |
≥98%（HPLC）
PF-562,271 has been used as a focal adhesion kinase (FAK) inhibitor to study its effects on the S100A9-induced tumor cell invasion in prostate cancer cell lines.PMID 32884282 It has also been used to study its effects on syndecan-1 (SDC-1) knockdown-induced upregulation of early growth regulator 1 (EGR1) in colon cancer cells.PMID 32477959
PF-562,271 is a potent, ATP-competitive, reversible and selective inhibitor of FAK and Pyk2. PF-562,271 inhibits FAK phosphorylation in vivo.
| 英文名称 | PF-562,271 |
| CAS 号 | 939791-38-5 |
| 经验分子式 | C21H20F3N7O3S · C6H6O3S |
| 分子量 | 665.66 |
| UNSPSC | 41121800 |
| NACRES | NA.77 |
| MDL 号 | MFCD14105612 |
| InChI | 1S/C21H20F3N7O3S.C6H6O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16;7-10(8,9)6-4-2-1-3-5-6/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30);1-5H,(H,7,8,9) |
| SMILES字符串 | CN（S（=O）（C）=O）C1=NC=CC=C1CNC2=C（C（F）（F）C=NC（NC3=CC4=C（C=C3）NC（C4）=O）=N2.O=S（C5=CC=CC=C5）（O）=O |
| InChI key | LKLWTLXTOVZFAE-UHFFFAOYSA-N |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至棕色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | 2-8°C |
| 包装规格（货号 PZ0387-5MG） | 5 mg |
| 包装规格（货号 PZ0387-25MG） | 25 mg |
