| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML2916-5MG | 5 mg | |
| SML2916-25MG | 25 mg |
≥98%（HPLC）
AAL-R [AAL(R)] is a FTY720 (fingolimod) analog and a much more rapidly activated sphingosine 1-phosphate receptor (S1P) agonist by sphingosine kinase 2 (SphK2)-mediated phosphorylation in vitro and in vivo. AAL-R triggers lymphocytes apoptosis in a SphK2-dependent manner (34%/84% remaining parental/SphK2-deficient Jurkat; 24 h 5 μM) with a significantly higher efficacy than its S-enantiomer AAL-S or FTY720 (%PI- mouse splenocytes = 27/ALL-R vs 56/FTY720 or ALL-S; 24 h 4 μM). AAL-R (0.1-0.3 mg/kg intratracheally), but not ALL-S, inhibits T-cell response to influenza infection and reduces pulmonary inflammation during Bordetella pertussis infection in mice (0.5 mg/kg intranasally).
更可磷酸化的FTY 720（芬戈莫德）类似物，具有更高的SphK 2依赖性1-磷酸鞘氨醇受体（S1 P）激动剂体外和体内功效。
| 英文名称 | AAL-R |
| CAS 号 | 241476-71-1 |
| 经验分子式 | C18H31NO2 |
| 分子量 | 293.44 |
| UNSPSC | 41106300 |
| NACRES | NA.77 |
| InChI | 1S/C18H31NO2/c1-3-4-5-6-7-14-21-17-10-8-16（9-11-17）12-13-18（2，19）15-20/h8-11，20H，3- 7，12 -15，19H2，1-2H3/t18-/m1/s1 |
| InChI key | ITJCKQTXCLGXHE-GOSISDBHSA-N |
| SMILES字符串 | C[C@](N)(CO)CCC1=CC=C(C=C1)OCCCCCCC |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | 2-8°C |
| 质量等级 | 100 |
| 包装规格（货号 SML2916-5MG） | 5 mg |
| 包装规格（货号 SML2916-25MG） | 25 mg |
