| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML2710-5MG | 5 mg | |
| SML2710-25MG | 25 mg |
≥98%（HPLC）
脑渗透剂，大麻素受体CB 1-选择性正变构调节剂（PAM），可阻断神经性疼痛，无拟大麻副作用。
ZCZ011 is a brain-penetrant, cannabinoid receptor CB1-selective positive allosteric modulator (PAM) that enhances orthosteric agonist CP55,940, while reduces orthosteric inverse agonist SR141716A, CB1 binding. ZCZ011 potentiates AEA-stimulated GTPγS binding (Emax = 46.5% without vs. 115.2% with 100 nM ZCZ011; mouse brain membranes) and cellular signaling (β-arrestin Emax = 100% without vs.157% with 100 nM ZCZ011, pERK pIC50 = 6.5 without vs. 8.3 with 10 nM ZCZ011; hCB1 cells). ZCZ011 exhibits antinociceptive efficay in murine chronic constriction injury (CCI) model of neuropathic pain & carrageenan model of inflammatory pain (40 mg/kg i.p.) without cannabimimetic side-effects.
| 英文名称 | ZCZ011 |
| CAS 号 | 1998197-39-9 |
| 经验分子式 | C21H18N2O2S |
| 分子量 | 362.44 |
| UNSPSC | 12352200 |
| NACRES | NA.77 |
| MDL 号 | MFCD31692973 |
| SMILES字符串 | [s]1c(ccc1)C(C[N+](=O)[O-])c2c3c([nH]c2c4ccccc4)cc(cc3)C |
| InChI key | RJSPNRDBWHHFMH-UHFFFAOYSA-N |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | 2-8°C |
| 质量等级 | 100 |
| 包装规格（货号 SML2710-5MG） | 5 mg |
| 包装规格（货号 SML2710-25MG） | 25 mg |
