| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML3969-5MG | 5 mg | |
| SML3969-25MG | 25 mg |
≥98%（HPLC）
Orally available, selective, high-affinity type-2 angiotensin II receptor (AT2R) antagonist with in vivo pain relief efficacy.
EMA401, the (3S)-enantiomer of EMA400 (PD-126,055), is a selective, high-affinity type-2 angiotensin II receptor (AT2R) antagonist (IC50 = 39.5 nM/>39 μM against 50 pM CGP 42112A for binding human AT2R/AT1R; IC50 = 39.5 nM/408 μM against 40 nM Ang II for binding rat AT2R/AT1R). EMA401, but not the AT1R antagonist losartan, is shown to inhibit capsaicin (200 nM) responses in cultured neurons of human and rat DRG (IC50 = 10 nM). EMA401 is orally available (F = 33.2%, t1/2 = 5.7 h, Cmax = 885 ng/mL post 10 mg/kg oral dosage in rats) and exhibits in vivo pain relief efficacy among adult male SD rats with a unilateral chronic constriction injury (CCI) of the sciatic nerve (ED50 = 10 μg/kg via i.p. using the racemate EMA400).
| 英文名称 | EMA401 sodium salt |
| CAS 号 | 1316755-17-5 |
| 经验分子式 | C32H28NNaO5 |
| 分子量 | 529.56 |
| UNSPSC | 12352200 |
| MDL 号 | MFCD30502664 |
| NACRES | NA.21 |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 储存条件 | 干燥 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | -10 到 -25°C |
| 质量等级 | 100 |
| 包装规格（货号 SML3969-5MG） | 5 mg |
| 包装规格（货号 SML3969-25MG） | 25 mg |
