Sigma-Aldrich 6, 2′, 4′-trimethoxyflavone，≥98%（HPLC）

产品概述

≥98%（HPLC）

生化/生理作用

AHR沿着免疫功能，也与内分泌过程和癌症发展相关。

6，2 ′，4 ′-三甲氧基黄酮是一种选择性的芳烃受体拮抗剂，无部分激动活性。

6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function.

制备/使用说明

6，2 ′，4 ′-三甲氧基黄酮可溶于DMSO中，浓度大于5 mg/ml。

技术规格