| 货号 | 包装规格 | 操作 |
|---|---|---|
| SML3632-5MG | 5 mg | |
| SML3632-25MG | 25 mg |
≥98%（HPLC）
Highly selective and high-affinity mu (μ) opioid receptor (MOR) antagonist in vitro and in vivo.
NAQ is a highly selective and high-affinity mu (μ) opioid receptor (MOR) antagonist with 241- & 48-fold selectivity over the delta (δ) and kappa (κ) opioid receptor, respectively (MOR/DOR/KOR Ki = 0.55/132.5/26.45 nM) and little MOR agonist activity (Emax = 15.83% of that of DAMGO by GTP[γS] binding using membrane from MOR-expressing cells). NAQ effectively antagonizes morphine antinociceptive effects in mice in vivo (warm-water tail immersion test AD50 = 0.45 mg/kg s.c. 5 min prior to 10 mg morphine/kg s.c.; no agonist efficacy up to 100 mg/kg).
| 英文名称 | NAQ |
| CAS 号 | 1236037-13-0 |
| 经验分子式 | C30H31N3O4·2HCl |
| 分子量 | 570.51 |
| UNSPSC | 12352116 |
| NACRES | NA.21 |
| SMILES字符串 | O[C@]12[C@@]34C5=C(C[C@H]2N(CC4)CC6CC6)C=CC(O)=C5O[C@@]3([H])[C@H](CC1)NC(C7=CC8=C(C=CC=C8)C=N7)=O.[2HCl] |
| 含量测定 | ≥98%（HPLC） |
| 形态 | 粉末 |
| 储存条件 | 干燥 |
| 颜色 | 白色至米色 |
| 溶解性 | DMSO: 2 mg/mL，清澈 |
| 储存温度 | 2-8°C |
| 质量等级 | 100 |
| 包装规格（货号 SML3632-5MG） | 5 mg |
| 包装规格（货号 SML3632-25MG） | 25 mg |
