Sigma-Aldrich Poly(M(EO)2MA:Poly(OEGMA)，(90：10），醛官能化的，25重量%的水溶液

产品概述

In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Aldehyde-functionalized PM(EO)2MA-co-OEGMA can be readily used with the corresponding hydrazide-functionalized POEGMA or PM(EO)2MA-co-OEGMA for rapid gelation via reversible hydrazone bond formationPMID 24531402. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricantsPMID 26648556. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degredation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.PMID 24911529

聚甲基丙烯酸二甘醇酯（低聚乙二醇甲基丙烯酸酯），（PM（EO）2 MA-co-OEGMA）是由接枝到疏水聚甲基丙烯酸酯主链上的亲水低聚物聚乙二醇（PEG）链组成的梳状接枝共聚物。在该材料中，PEG链是二甘醇单元或低聚物PEG（n=8-9）通过控制各组分的比例，可以调节所得材料的性质。在生物和生物材料应用中，POEGMA被认为是PEG的可行替代品。据报道，POEGMA可以改善蛋白质和肽缀合物PMID的药物动力学性质。19706892 PMID 20810920，提高siRNAsPMID 21480423的稳定性和基因沉默效率，作为生物传感器PMID 25170805的防污表面，并消除PEG抗原性PMID 28777555。

制备/使用说明

本产品以25wt%水溶液形式提供，可根据您的具体应用进行稀释。请参阅产品页面上的技术公告，了解稀释说明和水凝胶制备说明。

技术规格