Sigma-Aldrich Gold nanoparticles，15 nm直径，OD 50，甲基封端，PEG 5000涂层，分散在水中

产品概述

金纳米粒子（AuNPs）直径在2- 200 nm之间，具有良好的生物相容性和物理化学性质，是一种高灵敏度的胶体生物传感器，其应用领域十分广泛。在金纳米颗粒上的（乙二醇）（PEG）涂层有助于减少蛋白质吸附，减少了与细胞的非特异性相互作用，大大改善了这些纳米颗粒的药物动力学，并使纳米颗粒不能聚集。PEG层密度与AuNP曲率成反比。5000表现出最高的胶体稳定性。甲基基团是疏水性的，作为金纳米颗粒和亲水性外部PEG涂层之间的保护屏障，并且还导致AuNPs对蛋白质吸附和巨噬细胞摄取的进一步减少。PMID 23009596 PMID 21976982

应用领域

Several other specific applications have been listed below:
Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also used in biodistribution studies.AuNPs may also be used in photothermal therapy and radiotherapy.AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.PMID 23009596PMID 21976982

功能化粒子已被广泛用于研究纳米粒子的细胞摄取和靶向药物递送。

产品特点

PEG降低了GNP的细胞毒性，提高了GNP的靶向给药效率。PEG增加了纳米颗粒的稳定性，防止了纳米颗粒的团聚。PEG很容易与染料和巯基配体形成复合物。

技术规格