| 货号 | 包装规格 | 操作 |
|---|---|---|
| SBR00016-1ML | 1 mL |
50 mg/mL的DMSO溶液
Aminopterin is a synthetic derivative of pterin. It is used as a folic acid antagonist. It competitively inhibits dihydrofolate reductase (DHFR) and blocks tetrahydrofolate synthesis. This inhibition blocks DNA, RNA and protein synthesis.PMID 20268318PMID 22520983
Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.PMID 22520983
Aminopterin was first administered for cancer therapy, as a drug targeting metabolism, specifically in pediatric leukemia.PMID 18860765 Later on it was demonstrated to be more potent yet more toxic than methotrexate.PMID 14381889
| 英文名称 | Aminopterin Ready Made Solution |
| CAS 号 | 54-62-6 |
| 经验分子式 | C19H20N8O5 |
| 分子量 | 440.41 |
| UNSPSC | 12352205 |
| NACRES | NA.76 |
| MDL 号 | MFCD00036692 |
| InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27) |
| SMILES字符串 | OC(CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=NC3=C(N)N=C(N)N=C3N=C2)C=C1)=O)=O |
| InChI key | 俄罗斯联邦航空航天局 |
| 含量测定 | ≥85% |
| 形态 | 液体 |
| 储存条件 | 避免光照 |
| 集中 | 50 mg/mL的DMSO溶液 |
| 溶解性 | DMSO：50 mg/mL |
| 运输状态 | 干冰 |
| 储存温度 | −20°C |
| 质量等级 | 200 |
| 包装规格（货号 SBR00016-1ML） | 1 mL |
