| 货号 | 包装规格 | 操作 |
|---|---|---|
| 8.54000.0001 | 1 g | |
| 8.54000.0005 | 5 g |
Quasi-orthogonally-protected Lys derivative. The Fmoc group can be removed selectively by treatment with piperidine; the Dde group is cleaved with 2% hydrazine in DMF [1]. When removing Dde in the presence of allyl-based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group [2]. Also available Fmoc-Lys(Dde)-OH 852057. This derivative has been employed in Fmoc SPPS to facilitate the introduction of biotin to the side-chain of lysine [3].
Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS
Literature references
[1] B. W. Bycroft, et al. (1993) J. Chem. Soc., Chem. Commun., 778.
[2] B. Rohwedder, et al. (1998) Tetrahedron Lett., 39, 1175.
[3] J. Mack, et al. (1999) Lett. Pept. Sci., 6, 135.
颜色（目视检查）：白色至浅黄色至米色物质外观（目视检查）：粉末鉴别（IR）：通过检测对映体纯度：≥ 99. 5%（a/a）纯度（TLC（157 B））：纯度≥ 97%（TLC（CMA 2））：≥ 97%含量（HPLC，面积%）：≥ 96.0%（a/a）溶解度（1 mmol溶于2 ml DMF中）：可溶性含量（酸滴定法）：≥ 90.0%含水量（K. F.）：≤ 1.00%欲了解Novabiochem ®产品TLC所用的溶剂系统，请点击此处。
更换：04-12-5201
| 英文名称 | Dde-Lys(Fmoc)-OH |
| CAS 号 | 156648-40-7 |
| 经验分子式 | C31H36N2O6 |
| 分子量 | 532.63 |
| MDL 号 | MFCD00467662 |
| UNSPSC | 12352209 |
| NACRES | NA.22 |
| InChI key | CNDRLQTWKWIHEP-VWLOTQADSA-N |
| InChI | 1S/C31H36N2O6/c1-19(28-26(34)16-31(2,3)17-27(28)35)33-25(29(36)37)14-8-9-15-32-30(38)39-18-24-22-12-6-4-10-20(22)21-11-5-7-13-23(21)24/h4-7,10-13,24-25,33H,8-9,14-18H2,1-3H3,(H,32,38)(H,36,37)/t25-/m0/s1 |
| SMILES字符串 | N([C@@H](CCCCNC(=O)OCC2c3c(cccc3)c4c2cccc4)C(=O)O)C(=C1C(=O)CC(CC1=O)(C)C)C |
| 产品系列 | 新比奥肯® |
| 含量测定 | ≥90.0%（酸滴定法）; ≥96.0%（HPLC）; ≥97%（TLC） |
| 形态 | 粉末 |
| 反应适用性 | 反应类型：Fmoc固相肽合成 |
| 制造商/商标 | 新比奥肯® |
| 熔点 | >70 °C（分解） |
| 应用 | 肽合成 |
| 官能团 | 胺 |
| 储存温度 | 15-25°C |
| 质量等级 | 200 |
| 包装规格（货号 8.54000.0001） | 1 g |
| 包装规格（货号 8.54000.0005） | 5 g |
