Sigma-Aldrich PIM2, active, GST tagged human，PRECISIO®激酶，重组，在杆状病毒感染的Sf 9细胞中表达，≥70%（SDS-PAGE），甘油缓冲水溶液

产品概述

PRECISIO®激酶，重组，在杆状病毒感染的Sf 9细胞中表达，≥70%（SDS-PAGE），甘油缓冲水溶液

应用领域

PIM 2，活性的，GST标记的人已用于在PIM激酶在fms样酪氨酸激酶3抑制剂（FLT 3 i）抗性急性髓性白血病中的作用的研究中的体外激酶测定。PMID 26601252

生化/生理作用

PIM2 (proto-oncogene) is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, testis, small instestine and colon, as well as in spleen and thymus. It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells and during meiosis.PMID 9804974 PIM2 acts as a pro-survival kinase and BAD (BCL2 associated agonist of cell death) protein is a PIM2 substrate.PMID 12954615

物理形态

以50 mM Tris-HCl（pH 7.5）、150 mM NaCl、0.2 5 mM DTT、0.1 mM EGTA、0.1 mM EDTA、0.1 mM PMSF和25%甘油供应。

技术规格