Sigma-Aldrich FLT3 (571-993), active, GST tagged human，PRECISIO®激酶，重组，在杆状病毒感染的Sf 9细胞中表达，≥70%（SDS-PAGE），甘油缓冲水溶液

产品概述

FLT3 (fms-related tyrosine kinase 3) is a tyrosine kinase receptor and the gene is localized to human chromosome 13q12. The encoded protein is composed of 993 amino acids, and consists of five immunoglobulin (Ig)-like domains in its exoplasmic region. It is also composed of a transmembrane region, a juxtamembrane domain, and two tyrosine kinase domains in its intracellular domain. The tyrosine kinase domains are linked via a kinase-insert domain.PMID 24737502

生化/生理作用

FLT3（fms相关酪氨酸激酶3）与其配体相互作用后，发生构象变化形成同二聚体，导致磷酸化和激活下游信号通路，包括磷脂酰肌醇3-激酶（PI3K/AKT），丝裂原活化蛋白激酶/细胞外信号调节激酶PMID 24786392内部串联重复（ITD）突变或分别在质膜结构域编码区或激活环结构域内的点突变，FLT 3/ITD突变与急性髓细胞白血病（AML）发病的晚期阶段有关，这些患者预后差。PMID 24737502

物理形态

以50 mM Tris-HCl（pH 7.5）、150 mM NaCl、0.25 mM DTT、0.1 mM EGTA、0.1 mM EDTA、0.1 mM PMSF和25%甘油供应。

技术规格