Sigma-Aldrich FGFR3 (397-end), active, GST tagged human，PRECISIO®激酶，重组，在杆状病毒感染的Sf 9细胞中表达，≥70%（SDS-PAGE），甘油缓冲水溶液

产品概述

研究领域：癌症FGFR 3成纤维细胞生长因子受体3（fibroblast growth factor receptor 3，FGFR 3）是一种受体酪氨酸激酶（receptor tyrosine kinase，RTK），属于FGFR亚家族，由FGFR 1、FGFR 2、FGFR 3和FGFR 4四个成员组成，在其胞质结构域中含有一个配体结合区，一个跨膜区，PMID 25010350 FGFR 3对典型FGF配体具有强亲和力。

生化/生理作用

FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. PMID 15748888 This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma PMID 15748888 and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.PMID 24846059Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. PMID 15748888 FGFR3 also plays hepatoprotective function during liver damage. PMID 34646985

物理形态

以50 mM Tris-HCl（pH 7.5）、150 mM NaCl、0.2 5 mM DTT、0.1 mM EGTA、0.1 mM EDTA、0.1 mM PMSF和25%甘油供应。

技术规格