Sigma-Aldrich FLT1 (784-end), active, GST tagged human，PRECISIO®激酶，重组，在杆状病毒感染的Sf 9细胞中表达，≥70%（SDS-PAGE），甘油缓冲水溶液

产品概述

FLT1 (fms-related tyrosine kinase 1) or VEGFR (vascular endothelial growth factor receptor) is one of the receptor tyrosine kinase, which acts as a receptor for VEGF. VEGF is a predominant angiogenesis stimulating factor. FLT1 is a transmembrane receptor.PMID 24891316 Soluble FLT1 (sFLT1) is an alternatively spliced soluble form of FLT1, expressed by multiple tissues. It acts as a negative regulator of VEGF. It does not contain the cytosolic and transmembrane domains.PMID 25007257

生化/生理作用

FLT1 (fms-related tyrosine kinase 1) or VEGFR (vascular endothelial growth factor receptor) is implicated in angiogenesis in tumors, which plays a key role in tumorigenesis, invasion and metastasis of tumors, especially the malignant ones.PMID 24891316 In human circulation, angiogenesis is balanced by soluble FLT1 (sFLT1) and VEGF. An imbalance leads to multiple conditions such as pre-eclampsia.PMID 25007257 sFLT1 plays an essential role in the angiogenesis of placenta. An overexpression of this protein in placenta is associated with prenatal arsenic exposure and thus, reduced birth weight.PMID 24664213

物理形态

以50 mM Tris-HCl（pH 7.5）、150 mM NaCl、0.25 mM DTT、0.1 mM EGTA、0.1 mM EDTA、0.1 mM PMSF和25%甘油供应。

技术规格