Sigma-Aldrich Poly(M(EO)2MA:Poly(OEGMA) 90:10，酰肼官能化，25重量%（水溶液）

产品概述

酰肼官能化，25重量%（水溶液）

应用领域

In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degradation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solutionPMID 24911529.

This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution instructions and hydrogel preparation instructions.

Poly(diethylene glycol methacrylate)-co-(oligoethylene glycol methacrylate), (PM(EO)2MA-co-OEGMA) is a comb-shaped, graft copolymer consisting of hydrophilic oligomer polyethylene glycol (PEG) chains grafted to a hydrophobic polymethacrylate backbone. In this material, the PEG chains are either diethylene glycol units or oligomer PEG (n=8-9) units. Resulting material properties can be tuned by controlling the ratio of each component. POEGMA has been suggested as a viable alternative to PEG in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugatesPMID 19706892PMID 20810920, enhance the stability and gene silencing efficiency of siRNAsPMID 21480423, as an anti-fouling surface for biosensorsPMID 25170805, and eliminate PEG antigenicityPMID 28777555. In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Hydrazide-functionalized PM(EO)2MA-co-OEGMA can be readily used with the corresponding aldehyde-functionalized POEGMA or PM(EO)2MA-co-OEGMA for rapid gelation via reversible hydrazone bond formationPMID 24531402. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricantsPMID 26648556.

技术规格