Sigma-Aldrich IGF-Binding Protein 2 human，重组体，在（BTI-Tn-5B1 - 4）High-5昆虫细胞中表达，≥98%（SDS-PAGE），≥98%（HPLC），适用于细胞培养

产品概述

IGFBPs (insulin-like growth factor-binding proteins) are mainly required to regulate IGFs (insulin-like growth factors) activities. IGFBP-2 belongs to the IGFBP family of proteins. The protein has a IGF-binding site and a thyroglobulin type-1 domain. It interacts with IGF1 and IGF2.PMID 26317790 IGFBP-2 is widely expressed in tissues. This gene is mapped to human chromosome 2q35.
Recombinant human IGF-BP2 is a 31.5kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.

应用领域

人IGF-结合蛋白2已被用于研究在存在IGFBP-2的情况下转移性乳腺癌患者中疫苗刺激的增强免疫。

生化/生理作用

IGFBP-2 (insulin-like growth factor-binding protein 2) interacts with integrins and extracellular matrix via arginine-glycine-aspartic acid (RGD) and heparin-binding motifs. It participates in cell detachment, migration and invasion. IGFBP-2 is also associated with various malignancies, including ovarian cancer, breast cancer, colon cancer, lung cancer, prostate cancer, glioma and leukemia.PMID 26317790 It is suggested as a serum biomarker of Lupus Nephritis and is associated with the chronicity of renal pathology in patients. IGFBP-2 is upregulated in idiopathic pulmonary fibrosis.

物理形态

从1x PBS（pH 7.2）中冻干。

制备/使用说明

打开前将小瓶冲洗干净。用水复溶至浓度为0.1 - 1.0 mg/ml。不要涡旋。该溶液可在2 - 8 ° C下储存长达1周。为了延长储存时间，建议在含有载体蛋白（例如0.1% BSA）的缓冲液中进一步稀释，并在-20 °C至-80 °C下以工作等分试样储存。

其他说明

经皮给药后，经阴道给药后，经阴道给药。

技术规格