Sigma-Aldrich IGF-Binding Protein-5 human，重组体，在大肠杆菌中表达，≥98%（SDS-PAGE），≥98%（HPLC），适用于细胞培养

产品概述

IGFBP5 (insulin-like growth factor-binding protein 5) belongs to the IGFBP family of proteins. IGFBPs are mainly required to regulate IGFs (insulin like growth factors) activities. The gene IGFBP5 is mapped to human chromosome 2q35.PMID 26010068PMID 25248036
Recombinant human IGF-BP5 is a 28.6kDa protein consisting of 253 amino acid residues.

生化/生理作用

IGFBP5 (insulin-like growth factor-binding protein 5) works via IGF (insulin like growth factor)-dependent and -independent mechanisms. It can function as a tumor suppressor as well as an oncogene. Changes in the activity of this gene are often observed in human cancers and metastatic tissues. During cancer development, IGFBP5 is involved in cell growth, migration and invasion. IGFBP5 is associated with breast cancer, osteosarcoma, head and neck squamous cell carcinoma, neuroblastoma, prostate cancer and malignant melanoma.PMID 26010068 It is upregulated in systemic sclerosis and idiopathic pulmonary fibrosis. In primary fibroblasts, IGFBP5 exhibits pro-fibrotic effects. It is strongly expressed in bones and is involved in osteogenic differentiation.PMID 25827480 Under in vitro conditions, IGFBP5 and its microRNA (microRNA-143-3p) are involved in muscle regeneration.

物理形态

从10 mM柠檬酸钠（pH 3.0）中冻干。

制备/使用说明

打开前将小瓶冲洗干净。用水复溶至浓度为0.1 - 1.0 mg/ml。不要涡旋。该溶液可在2 - 8 ° C下储存长达1周。为了延长储存时间，建议在含有载体蛋白（例如0.1% BSA）的缓冲液中进一步稀释，并在-20 °C至-80 °C下以工作等分试样储存。

其他说明

本发明提供了一种用于检测汽车发动机曲轴箱曲轴

技术规格