| 货号 | 包装规格 | 操作 |
|---|---|---|
| R8526-100UG | 100 μg |
Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality.PMID 16297862 RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
人RO-52（SSA）已被用作酶联免疫吸附试验（ELISA）中的自身抗原阵列的一个组分，将蛋白质固定在自组装单层上。
RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies.PMID 16297862 RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
用于风湿性疾病中RNP抗体的检测和定量。
溶液含有20 mM磷酸盐缓冲液、500 mM NaCl、2 M-3 M尿素，pH 6。
| 英文名称 | RO-52 (SSA) human |
| UNSPSC | 12352202 |
| NACRES | NA.56 |
| MDL 号 | MFCD03458409 |
| 生物来源 | 人类 |
| 重组 | 在大肠杆菌中表达 |
| 形态 | 液体 |
| 分子量 | 52 kDa（SDS-PAGE法） |
| 技术 | 适用于 ELISA |
| UniProt 登录号 | P19474 |
| 储存温度 | −70°C |
| 质量等级 | 200 |
| 基因信息 | 人TRIM 21（6737） |
| 包装规格（货号 R8526-100UG） | 100 μg |
