Sigma-Aldrich Interleukin-6 Receptor Soluble Fragment human，重组，在Sf 21细胞中表达，≥97%（SDS-PAGE），冻干粉

产品概述

Interleukin-6 is a pleotropic cytokine involved in hematopoiesis, inflammation and immune response. IL-6 is secreted by macrophages, dendritic cells and B cells, in response to TNF-α, PGDF and IL-1. The signaling by IL-6 is mediated by heterodimeric receptor, IL-6R, comprising of IL-6Rα (soluble factor) and gp130 (sometimes called IL-6Rβ). Gp130 is crucial component for downstream signal transduction. In response to IL-6, gp130 activates kinases of JAK family, STATs, MAPK and Ras proteins. PMID 7668520PMID 17849470PMID 16707558 IL-6R-mediated signaling is essential for normal development of T and B cells PMID 18845487 and has been implicated in many diseases such as rheumatoid arthritis, Crohn disease, sepsis, fever, systemic lupus erythematosus, osteoporosis and insulin resistancePMID 17849470PMID 10340175PMID 15753533PMID 15230289
Interleukin-6 Receptor soluble fragment specifically binds and inhibits the activity of human IL-6 in free form or when bound to cell surface receptors.

应用领域

白细胞介素-6受体可溶性片段在1 - 10 ng/ml的浓度（EC 50）下在基于细胞的测定中使IL-6活性增加50%。

物理形态

从含1.25 mg牛血清白蛋白的磷酸盐缓冲盐水中的0.2 μ m过滤溶液中冻干。

分析说明

人IL-6受体可溶性片段的受体介导的活性通过其增加M1细胞的IL-6抑制的能力来测量。PMID 2051018

技术规格