| 货号 | 包装规格 | 操作 |
|---|---|---|
| SRP8040-50UG | 50 μg |
LAG3（淋巴细胞活化基因3）是抑制性CD4（分化簇）相关分子，并且由活化的CD4+和CD8 + T细胞表达。PMID 15485628
LAG3 (lymphocyte activation gene 3) is a negative regulator of T-cell proliferation where it suppresses T-cell receptor (TCR)-mediated calcium fluxes and modulates the memory T-cell pool size. It is a CD4 (cluster of differentiation) homolog that functions as a ligand for MHC (major histocompatibility complex) II. Membrane expression of LAG3 modulates the suppressive function of Tregs (T-regulatory) both in vivo and in vitro.PMID 15485628 HIV-1 (human immunodeficiency virus) infection results in significant increase in LAG3 peripheral blood and lymph node expression, which is exhibited on both CD4+ and CD8+ T cells, and this is linked with disease progression.PMID 25780040 In melanoma, this protein is responsible for TLR (Toll-like receptor)-independent activation of plasmacytoid dendritic cells (pDCs) at tumor sites, which is partially implicated in driving an immune-suppressive environment.PMID 24441096
PBS溶液。
编码人LAG-3的4个胞外Ig样结构域（D1-D4）的序列与人IgG1的Fc部分融合。
| 英文名称 | LAG-3 (human): FC (human) |
| NACRES | NA.32 |
| UNSPSC | 12352200 |
| 生物来源 | 人类 |
| 重组 | 在CHO细胞中表达 |
| 含量测定 | > 99%（SDS-PAGE） |
| 形态 | 液体 |
| 分子量 | 约80 kDa（SDS-PAGE法） |
| 包装 | 50 μg/包 |
| 集中 | ≥0.2 mg/mL |
| 杂质 | <0.1 EU/μ g内毒素，检测 |
| 颜色 | 明确 |
| UniProt 登录号 | P18627 |
| 运输状态 | 湿冰 |
| 储存温度 | −20°C |
| 基因信息 | 人LAG3（3902） |
| 包装规格（货号 SRP8040-50UG） | 50 μg |
