


| 货号 | 包装规格 | 操作 |
|---|---|---|
| I5278-25UG | 25 μg |
重组体,在NS0细胞中表达,冻干粉末,适用于细胞培养,≥ 95%(SDS-PAGE)
IGFBPs (insulin like growth factor binding proteins) regulate bioavailability of IGFs (insulin like growth factors) in cells. Binding between IGFs and IGFBPs reduces the availability of the IGFs. However, IGFBPs also concentrate IGFs in specific areas to potentiate their effects at right time.PMID 25475528 IGFBP3 binds to IGF-1.PMID 25548030 It is a tumor suppressor and is downregulated in many cancers.PMID 25662950 In serum, IGFs, IGFBP3 and the acid labile subunit (ALS) exist together as a complex. This complex is important for increasing the half life of serum IGFs.PMID 12235108
人IGFBP-3是血浆中主要的胰岛素样生长因子(IGF)结合蛋白,其与IGF-I或IGF-II和酸不稳定亚基(ALS)以三元复合物形式存在。
在30%乙腈和0.1% TFA中,用0.2 μm过滤溶液冻干。
生物活性是以抑制14ng/ml重组人IGF-I对MCF-7细胞的生物活性的能力来测量的。
| 英文名称 | Insulin-Like Growth Factor Binding Protein-3 human |
| UNSPSC | 51111800 |
| NACRES | NA.32 |
| MDL 号 | MFCD00285941 |
| 生物来源 | 人类 |
| 重组 | 在NSO细胞中表达 |
| 含量测定 | ≥95%(SDS-PAGE法) |
| 形态 | 冻干粉 |
| 效价 | 0.01 - 0.25微克/毫升 |
| 分子量 | 29 kDa |
| 包装 | 25 μg包装 |
| 储存条件 | 避免反复冻融 |
| 技术 | 细胞培养 | 哺乳动物:适用 |
| 杂质 | 内毒素,检测 |
| UniProt 登录号 | P17936 |
| 储存温度 | −20°C |
| 质量等级 | 100 |
| 基因信息 | 人IGFBP 3(3486) |
| 包装规格(货号 I5278-25UG) | 25 μg |