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Sigma-Aldrich HSP70, His tagged human,重组体,在杆状病毒感染的Sf 9细胞中表达,≥70%(SDS-PAGE),甘油缓冲水溶液

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Sigma-Aldrich HSP70, His tagged human,重组体,在杆状病毒感染的Sf 9细胞中表达,≥70%(SDS-PAGE),甘油缓冲水溶液

Sigma-Aldrich HSP70, His tagged human,recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
SIGMA-ALDRICH授权代理生化试剂
CAS 号 2071612-66-1品牌 Sigma-Aldrich类目 实验室试剂 / 生化试剂更新日期 2026-10-18

规格与货号

货号包装规格操作
SRP5190-50UG50 μg

产品概述

Heat shock protein 70 (HSP70) is a ubiquitous molecular chaperone. It comprises an N-terminal domain, nucleotide-binding domain (NBD), substrate-binding domain (SBD), and a C-terminal domain.PMID 31253954

应用领域

Heat shock protein 70 (HSP70), His tagged human has been used:
to study the interaction between HSP70 and receptor of advanced glycation endproducts (RAGE) using protein proximity ligand assay (PLA) PMID 27858225to facilitate the import of superoxide dismutase 2 (SOD2) into the mitochondriaPMID 30485823to study its role in muscle catabolismPMID 28928431

生化/生理作用

Heat shock protein 70 (HSP70) plays a role in the cellular protein folding and remodeling process. It is also involved in the translocation of polypeptides into the chloroplast, mitochondria, and endoplasmic reticulum.PMID 31253954 HSP70 facilitates dismantling of protein complexes and modulates protein activity.PMID 31253954 It also plays a role in guarding cells from proteotoxic stress, pathophysiological conditions, and organismal aging.PMID 31253954 HSP70 participates in the activation of several immune cells such as macrophages, natural killer (NK) cells, B lymphocytes, peripheral monocytes, and antigen-presenting cells (APCs).PMID 27858225

物理形态

以50 mM磷酸钠(pH 7.0)、300 mM NaCl、150 mM咪唑、0.1 mM PMSF、0.25 mM DTT、25%甘油供应。

制备/使用说明

开封后,分装成较小的量并储存在-70 °C下。避免重复处理和多次冻融循环

技术规格

英文名称HSP70, His tagged human
CAS 号2071612-66-1
NACRESNA.32
UNSPSC12352200
生物来源人类
重组在杆状病毒感染的Sf 9细胞中表达
含量测定≥70%(SDS-PAGE)
形态缓冲水性甘油溶液
分子量约70 kDa
NCBI 登录号NM_005345
应用细胞分析
运输状态干冰
储存温度−70°C
基因信息人... HSPA 1A(3303)
包装规格(货号 SRP5190-50UG)50 μg

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