Sigma-Aldrich HDAC6 H216A human，重组，在杆状病毒感染的Sf 9细胞中表达，≥75%（SDS-PAGE）

产品概述

HDAC6组蛋白去乙酰化酶6（histone deacetylase 6）属于HDAC蛋白家族，负责核内组蛋白和非组蛋白的去乙酰化，包括转录因子。H216 A突变导致无催化活性的HDAC 6。H216 A突变的人HDAC 6（GenBank登录号NM_006044），具有N-末端GST标签的全长，MW= 161 kDa，在杆状病毒表达系统中表达。

生化/生理作用

HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis.PMID 26848526 HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility.PMID 26763233PMID 26747087 It is also involved in the formation of SGs (stress granules) and SG proteins.PMID 26747087 Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.

技术规格