Sigma-Aldrich Akt1 active human，重组，在杆状病毒感染的Sf 9细胞中表达，≥75%（SDS-PAGE）

产品概述

AKT1 (v-akt murine thymoma viral oncogene homolog 1) is a Ser/Thr protein kinase, and is also called protein kinase B (PKB). This protein is activated when it is phosphorylated at serine 473 and threonine 308.PMID 25582346 This gene is localized to human chromosome 14q32.32.PMID 16098065

应用领域

Akt1活性人已用于使用体外蛋白激酶测定法检测重组小鼠p21蛋白作为其底物。PMID 24848107

生化/生理作用

AKT1 (v-akt murine thymoma viral oncogene homolog 1) is responsible for the phosphorylation and cytoplasmic localization of CKDN1A (cyclin-dependent kinase (CDK) inhibitor 1, also referred to as p21). However, p21 is one of the CDKNs which normally resides in the nucleus and its cytoplasmic localization, mediated by AKT1, is common to various cancers where it suppresses proteins essential for apoptosis.PMID 24848107 Studies show that up-regulation of AKT1 serves as a poor prognostic marker in breast cancer, which however, depends upon factors including population, hormone receptor status, and hormonal or trastuzumab therapy status.PMID 25582346

技术规格