Sigma-Aldrich GSK3β，活性，人，重组，在杆状病毒感染的Sf 9细胞中表达，≥80%（SDS-PAGE）

产品概述

Glycogen Synthase Kinase 3β (GSK3β) is one of the two isoforms of GSK3 enzyme, both of which are encoded by different genes. This protein is predominantly cytoplasmic, but is also found to be localized to nucleus and mitochondria.PMID 15102436 It is a protein-serine kinase.PMID 10894547 This protein contains a protein kinase domain in its core, and is composed of 482 amino acids with a molecular weight of 46,712Da. It shows a wide range of tissue expression with the highest expression in brain.PMID 11527574

人GSK 3 β GenBank登录号NM_002093），具有N-末端GST-标签的全长，MW=73 kDa，在杆状病毒感染的Sf 9细胞表达系统中表达。

应用领域

可用于酶动力学研究、筛选抑制剂和选择性分析。

生化/生理作用

Glycogen Synthase Kinase 3β (GSK3β) is responsible for rapid cyclin D1 turnover by phosphorylating it on Thr-286.PMID 9832503 It functions as a negative regulator of Wnt signaling during embryonic development and cell proliferation in adult tissues.PMID 10894547 This protein phosphorylates and regulates multiple proteins such as glycogen synthase, insulin receptor substrate-1, axin and APC (adenomatous polyposis coli). This protein is also shown to interact with multiple protein which are linked with Alzheimer′s disease (AD).PMID 11527574

技术规格