Sigma-Aldrich 官能化金纳米粒子COOH，40 nm直径，羧酸官能化，PEG 3000涂覆，OD 50，分散在H2O中

产品概述

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between the negatively charged carboxylate groups and positively charged amino groups of protein. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.PMID 18486946PMID 23009596

应用领域

功能化颗粒已被广泛用于研究纳米颗粒的细胞摄取和靶向药物递送。

下面列出了其他几种具体应用：由于它们粘附在细胞膜上，AuNPs可以在靶向药物递送应用中用于细胞和细胞内靶向，并且还可以用于生物分布研究。AuNPs还可以用于光热疗法和放射疗法。研究表明，AuNPs的范围为10至250 nm，主要被肝脏和脾脏吸收，当静脉注射到大鼠体内时，10 nm的纳米颗粒更广泛地分布在各种器官中。羧酸端基与各种蛋白质结合，因此用于靶向药物递送和基因治疗。PMID 18486946 PMID 23009596 PMID 21976982

产品特点

PEG涂层降低了GNP的细胞毒性并提高了GNP在靶向药物递送中的效率。PEG增加了纳米颗粒的稳定性并防止团聚。

技术规格